Dietary flavonoids and risk of stroke in women.
نویسندگان
چکیده
BACKGROUND AND PURPOSE To date, few studies have examined associations between the wide range of flavonoid subclasses and risk of ischemic, hemorrhagic, and total stroke. METHODS We conducted a prospective study among 69 622 women from the Nurses' Health Study. Total flavonoid and subclass intakes were calculated from semiquantitative food frequency questionnaires collected every 4 years using an updated and extended US Department of Agriculture flavonoid database. RESULTS During 14 years of follow-up, 1803 incident strokes were confirmed. After adjusting for potential confounders, women in the highest compared with the lowest quintile of flavanone intake had a relative risk of ischemic stroke of 0.81 (95% CI, 0.66-0.99; P=0.04). Citrus fruits/juices, the main dietary source of flavanones, tended to be associated with a reduced risk for ischemic stroke (relative risk, 0.90; 95% CI, 0.77-1.05) comparing extreme quintiles. CONCLUSIONS Total flavonoid intake was not inversely associated with risk of stroke; however, increased intake of the flavanone subclass was associated with a reduction in the risk of ischemic stroke. Citrus fruit consumption may be associated with a reduction in stroke risk, and experimental data support these epidemiological associations that the flavanone content of citrus fruits may potentially be cardioprotective. Further prospective studies are needed to confirm these associations.
منابع مشابه
Dietary flavonoid intake and the risk of stroke: a dose-response meta-analysis of prospective cohort studies
OBJECTIVE To clarify and quantify the potential association between intake of flavonoids and risk of stroke. DESIGN Meta-analysis of prospective cohort studies. DATA SOURCE Studies published before January 2016 identified through electronic searches using PubMed, Embase and the Cochrane Library. ELIGIBILITY CRITERIA FOR SELECTING STUDIES Prospective cohort studies with relative risks and ...
متن کاملDietary flavonoid intake and risk of cardiovascular disease in postmenopausal women.
Flavonoids, a group of phenolic compounds found in fruits and vegetables, are known to have antioxidant properties. They prevent low density lipoprotein oxidation in vitro and thus may play a role in the prevention of coronary heart disease (CHD). In 1986, in a prospective study of 34,492 postmenopausal women in Iowa, the authors examined the association of flavonoid intake with CHD and stroke ...
متن کاملDietary Patterns and Risk of Breast Cancer among Pre and Post-Menopausal Women: A Case-Control Study in Iran
Background: Most of previous studies have investigated the association of specific food or nutrient with risk of breast cancer (BC) rather than overall diet and there is lack of evidence regarding dietary pattern in BC development. This study aims to examine the association between dietary patterns and risk of BC among Iranian women. Methods: This case–control study was carried out on 453 BC wo...
متن کاملPrevalence of post-stroke depression and its relationship with risk factors for stroke
Background & Objective: Stroke is a major public health problem. Post-stroke depression is one of the common emotional disorders afflicting stroke survivors. The purpose of this study was to determine of the prevalence of depression and its relationship with risk factors for stroke after an episode of stroke. Materials & Methods: This descriptive study was performed on 100 consecutive patients ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Stroke
دوره 43 4 شماره
صفحات -
تاریخ انتشار 2012